Un agente del FBI tiene que escoltar a un testigo desde Hawaii a Los Ángeles. Para intentar que dicho testigo testifique, un asesino libera cientos de serpientes venenosas en el avión comercial en pleno vuelo. El agente del FBI, un piloto novato y una tripulación aterrorizada intentarán sobrevivir como sea a la mortal invasión
Snakes On a Plane (Bring It) — Cobra Starship
Black Mamba (Teddybears Remix) — The Academy Is...
The Only Difference Between Martyrdom and Suicide Is Press Coverage (Tommie Sunshine Brooklyn Fire Remix) — Panic! At The Disco
Can't Take It (El Camino Prom Wagon Mix) — The All-American Rejects
Ophidiophobia — CeeLo Green
Of All the Gun Joints In All the World (Tommie Sunshine's Brooklyn Fire Retouch) — Fall Out Boy
New Friend Request (Hi-Tek Mix) — Gym Class Heroes
Remember to Feel Real (Machine Shop Remix) — Armor for Sleep
Bruised (Snakes Remix) — Jack's Mannequin
Wake Up (Acoustic Version) — Coheed and Cambria
Wine Red (Tommie Sunshine's Brooklyn Fire Retouch) — The Hush Sound
Lovely Day — Donavon Frankenreiter
Around the Horn (Louis the IV Mix) — The Bronx
Snakes On a Plane - The Theme — Trevor Rabin
Hey Now Now — Michael Franti & Spearhead
Queen of Apology (Fall Out Boy Mix) — The Sounds
Henehene Kou 'Aka — Israel Kamakawiwo'ole
Snakes On Crack — Trevor Rabin
Snakes Spread — Trevor Rabin
Sorting It Out — Trevor Rabin
Oxygen Masks — Trevor Rabin
Going Down — Trevor Rabin
Serpent Situation — Trevor Rabin
Anti-Venom Hope — Trevor Rabin
Reptile Wrecker — Trevor Rabin
Evacuation — Trevor Rabin
Snake Kabab — Trevor Rabin
Snake Chaos — Trevor Rabin
Snakes Kill — Trevor Rabin